ABSTRACT
Drug dependence has been a severe social and health problem,which has caused serious economic losses and social disorder in China.The critical problem in drug dependence is repeated relapse even after detoxification.We have been contributed to the research of neurobiological mechanisms,clinical characteristics,and interventions of craving after withdrawal from addicting drugs.We have systemati-cally studied the change of drug seeking behavior and craving after withdrawal from cocaine,and further investigated the neural anatomic pathway,long-term neuroplasticity,and neural signal pathways which involved in the change of drug seeking behavior.According to the situation of dug abuse in China,we investigated the characteristics in the expression of incubation of craving after withdrawal from opiate.We have primarily found the neural anatomic pathways and neural plasticity mechanisms which contribute to the process.We have also demonstrated the psychological characteristics and neurobiological mechanisms of craving induced by opiate and its long-term maintenance resulting from learning and memory,chronobiology and imaging.Our findings have provided evidence for effective inventions on preventing relapse after abstinence in addicts.Abstract:SUMM ARY Drug dependence has been a severe social and health problem,which has caused serious e-conom ic losses and social d isorder in China.The critical problem in drug dependence is repeated relapse even after detoxification.W e have been contributed to the research of neurobiologicalmechanisms,clini-cal characteristics,and interventions of craving afterwithdrawal from add icting drugs.W e have systemati-cally stud ied the change of drug seeking behavior and craving afterwithdrawal from cocaine,and further investigated the neural anatom ic pathway,long-term neuroplasticity,and neural signal pathways which involved in the change of drug seeking behavior.Accord ing to the situation of dug abuse in China,we in-vestigated the characteristics in the expression of incubation of craving after withdrawal from opiate.W e have primarily found the neural anatom ic pathways and neural plasticity mechanisms which contribute to the process.W e have also demonstrated the psychological characteristics and neurobiologicalmechanisms of craving induced by opiate and its long-term maintenance resulting from learning and memory,chrono-biology and imaging.Our find ings have provided evidence for effective inventions on preventing relapse after abstinence in add icts.